Encephalopathy in Graded Portacaval Shunts

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Progressive reduction of sleep time and quality in rats with hepatic encephalopathy caused by portacaval shunts.

Patients with liver cirrhosis show sleep disturbances. Insight into their relationship with hepatic encephalopathy (HE) can be obtained using animal models of HE. The aims of this work were to assess (1) whether rats with portacaval shunts (PCS), a model of HE, show alterations in sleep and if they are similar to those in patients with HE; (2) Whether hyperammonemia plays a role in these sleep ...

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ژورنال

عنوان ژورنال: Annals of Surgery

سال: 1966

ISSN: 0003-4932

DOI: 10.1097/00000658-196612000-00009